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Neural Dev. 2009 Jul 6;4:25. doi: 10.1186/1749-8104-4-25.

Retinal waves are unlikely to instruct the formation of eye-specific retinogeniculate projections.

Author information

1
Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, School of Medicine, University of California, Davis, CA 95616, USA. lmchalupa@ucdavis.edu

Abstract

In all mammalian species the projections of the two eyes to the dorsal lateral geniculate nucleus are initially overlapping before gradually forming the eye-specific domains evident at maturity. It is widely thought that retinal waves of neuronal activity play an instructional role in this developmental process. Here, I discuss the myriad reasons why retinal waves are unlikely to have such a role, and suggest that eye-specific molecular cues in combination with neuronal activity are most probably involved in the formation of eye-specific retinogeniculate projections.

PMID:
19580684
PMCID:
PMC2706240
DOI:
10.1186/1749-8104-4-25
[Indexed for MEDLINE]
Free PMC Article

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