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Diabetes Technol Ther. 2009 Jul;11(7):457-60. doi: 10.1089/dia.2008.0083.

Daily glucose profiles in Japanese people with normal glucose tolerance as assessed by continuous glucose monitoring.

Author information

1
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. ms97-tsujino@jikei.ac.jp

Abstract

BACKGROUND:

Little information is available regarding glucose fluctuations in postprandial states and during the oral glucose tolerance test (OGTT) in Japanese people with normal glucose tolerance (NGT).

METHODS:

Glucose profiles of 27 Japanese people were measured for 4 days by using continuous glucose monitoring. A 75-g OGTT was conducted on the second day, and 24 subjects diagnosed with NGT by a 75-g OGTT were enrolled. The subjects were monitored for their postprandial glucose profile in their ordinary daily life on the third day.

RESULTS:

The results of our study have shown that the median time (interquartile range) to maximum glucose levels in OGTT was 38 (25-49) min after glucose load and that the median time to maximum glucose levels after breakfast, lunch, and dinner was 40 (31-75), 50 (30-70), and 45 (36-50) min, respectively. The median increase in glucose during OGTT was 45 (35-66) mg/dL, and that after breakfast, lunch and dinner was 21 (12-32), 37 (27-48), and 44 (25-63) mg/dL, respectively. Those with a higher insulinogenic index reached their maximum glucose levels in a shorter time (r = -0.46, P = 0.025) and had smaller glucose increments during OGTT (r = -0.49, P = 0.014).

CONCLUSIONS:

This study is the first report to document the glucose profile of Asian people with NGT.

PMID:
19580360
DOI:
10.1089/dia.2008.0083
[Indexed for MEDLINE]

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