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Arq Gastroenterol. 2009 Apr-Jun;46(2):97-101.

Seroprevalence of Helicobacter pylori in patients with colon adenomas in a Brazilian university hospital.

Author information

1
Gastroenterology Unit, Hospital das Clínicas, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. agbuso@yahoo.com.br

Abstract

CONTEXT:

The association between Helicobacter pylori infection and colon neoplasia has been the subject of recent investigations which have produced controversial results.

OBJECTIVE:

To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal.

METHODS:

After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls). The groups were similar regarding age and gender. The individuals of both groups were subjected to a dosage of IgG antibody against H. pylori. The dosage was applied according to the solid phase, chemiluminescent immunometric assay. The chi-square test was used to analyze the data.

RESULTS:

There were 30 men and 64 women in each group (94 cases and 94 controls). The mean age of the cases was 59.79 +/- 12.25 years and that of the controls was 58.98 +/- 11.55 years. The H. pylori serology was positive for 66 (70.21%) of the cases and for 51 (54.25%) of the controls. There was a significant difference (P = 0.024). The odds ratio was 1.98 (CI 95%, 0.82-3.15). The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038).

CONCLUSION:

There is a positive association between H. pylori infection and colonic adenomas. This association is more evident in women, especially for tubular adenomas and distal colonic location.

PMID:
19578608
DOI:
10.1590/s0004-28032009000200004
[Indexed for MEDLINE]
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