Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Neurosci. 2009 Aug;12(8):1042-9. doi: 10.1038/nn.2348. Epub 2009 Jul 5.

Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning.

Author information

1
Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK.

Abstract

Although feedforward inhibition onto Purkinje cells was first documented 40 years ago, we understand little of how inhibitory interneurons contribute to cerebellar function in behaving animals. Using a mouse line (PC-Deltagamma2) in which GABA(A) receptor-mediated synaptic inhibition is selectively removed from Purkinje cells, we examined how feedforward inhibition from molecular layer interneurons regulates adaptation of the vestibulo-ocular reflex. Although impairment of baseline motor performance was relatively mild, the ability to adapt the phase of the vestibulo-ocular reflex and to consolidate gain adaptations was strongly compromised. Purkinje cells showed abnormal patterns of simple spikes, both during and in the absence of evoked compensatory eye movements. On the basis of modeling our experimental data, we propose that feedforward inhibition, by controlling the fine-scale patterns of Purkinje cell activity, enables the induction of plasticity in neurons of the cerebellar and vestibular nuclei.

PMID:
19578381
PMCID:
PMC2718327
DOI:
10.1038/nn.2348
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center