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Nat Genet. 2009 Aug;41(8):899-904. doi: 10.1038/ng.407. Epub 2009 Jul 5.

Genome-wide association study identifies five susceptibility loci for glioma.

Author information

1
Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

Abstract

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.

PMID:
19578367
PMCID:
PMC4501476
DOI:
10.1038/ng.407
[Indexed for MEDLINE]
Free PMC Article

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