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Nat Chem Biol. 2009 Sep;5(9):625-7. doi: 10.1038/nchembio.189. Epub 2009 Jul 5.

Bacillithiol is an antioxidant thiol produced in Bacilli.

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1
Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, California, USA.

Abstract

Glutathione is a nearly ubiquitous, low-molecular-mass thiol and antioxidant, but it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a newly described and abundant thiol produced by Bacillus species, Staphylococcus aureus and Deinococcus radiodurans. Bacillithiol is the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid and most probably functions as an antioxidant. Bacillithiol, like the structurally similar mycothiol, may serve as a substitute for glutathione.

PMID:
19578333
PMCID:
PMC3510479
DOI:
10.1038/nchembio.189
[Indexed for MEDLINE]
Free PMC Article

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