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Indian Pediatr. 2010 Feb;47(2):131-7. Epub 2009 May 20.

Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multi center randomized controlled trial.

Author information

1
Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

OBJECTIVE:

To evaluate whether light-emitting diode (LED) phototherapy is as efficacious as compact fluorescent tube (CFT) phototherapy for the treatment of non-hemolytic jaundice in healthy term and late preterm neonates.

STUDY DESIGN:

Multi centre open label randomized controlled trial.

SETTING:

Four tertiary care neonatal units.

SUBJECTS:

Healthy term and late preterm neonates with non-hemolytic jaundice.

INTERVENTION:

Single-surface LED or CFT phototherapy.

PRIMARY OUTCOME VARIABLE:

Duration of phototherapy.

RESULTS:

A total of 272 neonates were randomized to receive LED (n=142) or CFT (n=130) phototherapy. The baseline demographic and biochemical variables were similar in the two groups. The median duration of phototherapy (IQR) in the two groups was comparable (26 (22-36) h vs. 25(22-36) h; P=0.44). At any time point, a similar proportion of neonates were under phototherapy in the two groups (log-rank test, P=0.38). The rate of fall of serum total bilirubin (STB) during phototherapy and the incidence of failure of phototherapy were also not different. An equal proportion of neonates had a rebound increase in STB needing restarting of phototherapy. Side effects were rare, comparable in the two groups and included hypothermia, hyperthermia, rash, skin darkening and dehydration.

CONCLUSIONS:

LED and CFT phototherapy units were equally efficacious in the management of non-hemolytic hyperbilirubinemia in healthy term and late preterm neonates.

PMID:
19578227
DOI:
10.1007/s13312-010-0020-7
[Indexed for MEDLINE]
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