Format

Send to

Choose Destination
See comment in PubMed Commons below
EuroIntervention. 2009 May;5(1):133-9.

Characterisation of atherosclerotic plaque by spectral similarity of radiofrequency intravascular ultrasound signals.

Author information

1
Boston Scientific Corporation, Fremont, CA, USA. sathyans@bcsi.com

Abstract

AIMS:

The aim of this paper is to report a method of atherosclerotic plaque tissue characterisation based on pattern recognition and assess its accuracy under conditions of potential clinical relevance.

METHODS AND RESULTS:

Excised saline infused human arteries were imaged using IVUS with RF acquisition. 40% of the vessels were re-imaged with human blood infusion. A database of approximately 12000 image regions-of-interest (ROIs) of histologically established types was used to design a pattern recognition algorithm to predict the tissue type of a given ROI by comparing its RF-spectrum against the database, and also to estimate the confidence of prediction. Ex vivo validation demonstrated accuracies at the highest level of confidence as: 97%, 98%, 95%, and 98% for necrotic, lipidic, fibrotic and calcified regions respectively. Good agreement with histology was shown in an in vivo swine animal model.

CONCLUSIONS:

Ex vivo validation demonstrated the ability to characterise plaque tissue using an IVUS+RF system and a method incorporating (1) full spectral information (2) spectral similarity (3) estimating confidence of characterisation and, (4) ability to characterise plaque imaged through blood. Promising results were demonstrated in a live animal model. This approach may have potential for accurate and reproducible plaque characterisation in vivo.

PMID:
19577995
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center