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J Pharm Biomed Anal. 2009 Dec 5;50(5):718-23. doi: 10.1016/j.jpba.2009.05.036. Epub 2009 Jun 6.

NMR analysis, protonation equilibria and decomposition kinetics of tolperisone.

Author information

1
Department of Pharmaceutical Chemistry, Semmelweis University, Research Group of Drugs of Abuse and Doping Agents, Hungarian Academy of Sciences, Budapest H-1092, Hogyes Endre u. 9, Hungary.

Abstract

The rate constants of spontaneous and hydroxide-catalyzed decomposition and the tautomer-specific protonation constants of tolperisone, a classical muscle relaxant were determined. A solution NMR method without any separation techniques was elaborated to quantitate the progress of decomposition. All the rate and equilibrium constants were determined at four different temperatures and the activation parameters were calculated. The molecular mechanism of decomposition is proposed.

PMID:
19577875
DOI:
10.1016/j.jpba.2009.05.036
[Indexed for MEDLINE]

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