Format

Send to

Choose Destination
J Psychiatr Res. 2009 Dec;43(16):1246-52. doi: 10.1016/j.jpsychires.2009.05.006. Epub 2009 Jul 4.

Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk?

Author information

1
Department of Psychiatry and Behavioral Sciences, Stanford Medical Center, 401 Quarry Rd, Room 1316, Stanford, CA 94305-5722, USA. btaylor@stanford.edu

Abstract

To determine if improvement in mood would ameliorate autonomic dysregulation, HPA dysfunction, typical risk factors and C-reactive protein in depressed patients with elevated cardiovascular disease risk (CVD), 48 depressed participants with elevated cardiovascular risk factors were randomized to a cognitive behavioral intervention (CBT) or a waiting list control (WLC) condition. Twenty non-depressed age and risk-matched controls were also recruited. Traditional risk factors (e.g., lipids, blood pressure) and C-reactive protein were assessed pre- and post-treatment six months later. Subjects also underwent a psychophysiological stress test while cardiovascular physiology was measured. Salivary cortisol was measured during the day and during the psychological stress test. At post-treatment, the CBT subjects were significantly less depressed than WLC subjects. There was no significant difference in change scores on any of the traditional risk factors or C-reactive protein, cortisol measures, or cardiovascular physiology, except for triglyceride levels and heart rate, which were significantly lower in treatment compared to control subjects. The normal controls exhibited no change in the variables measured during the same time. A significant improvement in mood may have little impact on most traditional or atypical risk factors, cortisol or cardiophysiology.

PMID:
19577757
PMCID:
PMC2783820
DOI:
10.1016/j.jpsychires.2009.05.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center