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Trends Microbiol. 2009 Jul;17(7):286-94. doi: 10.1016/j.tim.2009.04.005. Epub 2009 Jul 2.

Functional annotations for the Saccharomyces cerevisiae genome: the knowns and the known unknowns.

Author information

1
Department of Genetics, Stanford University Medical School, Stanford, CA 94305-5120, USA.

Abstract

The quest to characterize each of the genes of the yeast Saccharomyces cerevisiae has propelled the development and application of novel high-throughput (HTP) experimental techniques. To handle the enormous amount of information generated by these techniques, new bioinformatics tools and resources are needed. Gene Ontology (GO) annotations curated by the Saccharomyces Genome Database (SGD) have facilitated the development of algorithms that analyze HTP data and help predict functions for poorly characterized genes in S. cerevisiae and other organisms. Here, we describe how published results are incorporated into GO annotations at SGD and why researchers can benefit from using these resources wisely to analyze their HTP data and predict gene functions.

PMID:
19577472
PMCID:
PMC3057094
DOI:
10.1016/j.tim.2009.04.005
[Indexed for MEDLINE]
Free PMC Article

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