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Yao Xue Xue Bao. 1991;26(3):228-30.

[Antimalarial activity of deoxoqinghaosu].

[Article in Chinese]

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Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.


Compound 3 (deoxoqinghaosu) and compound 4 (deoxocarbaqinghaosu) were synthesized from arteannuic acid (2). Primary exploration of their antimalarial effect against K173 strain of Plasmodium berghei shows that compound 3 is somewhat more effective than the natural compound--qinghaosu. However, the carba-analogue compound 4 is almost ineffective. The enhanced activity of compound 3 is supposedly ascribed to its higher lipophilicity and, hence, higher affinity for plasmodial membrane. Further studies are in progress.

[Indexed for MEDLINE]

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