Send to

Choose Destination
Annu Rev Cell Dev Biol. 2009;25:133-60. doi: 10.1146/annurev.cellbio.042308.113302.

Molecular circuitry of endocytosis at nerve terminals.

Author information

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.


Presynaptic terminals are specialized compartments of neurons responsible for converting electrical signals into secreted chemicals. This self-renewing process of chemical synaptic transmission is accomplished by the calcium-triggered fusion of neurotransmitter-containing vesicles with the plasma membrane and subsequent retrieval and recycling of vesicle components. Whereas the release of neurotransmitters has been studied for over 50 years, the process of synaptic vesicle endocytosis has remained much more elusive. The advent of imaging techniques suited to monitor membrane retrieval at presynaptic terminals and the discovery of the molecules that orchestrate endocytosis have revolutionized our understanding of this critical trafficking event.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center