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Cornea. 2009 Aug;28(7):829-31. doi: 10.1097/ICO.0b013e318191449a.

Immunotactoid microtubular corneal deposits in bilateral paraprotein crystalline keratopathy.

Author information

1
Department of Pathology, Rhode Island Hospital and Miriam Hospital, Providence, RI 02903, USA. kamallabana@rediffmail.com

Abstract

PURPOSE:

To report an ultrastructurally distinct form of paraprotein crystalline keratopathy.

METHODS:

Three corneas submitted from a single patient including one native cornea from each eye and a failed corneal graft from the right eye. Light microscopy, immunohistochemistry, immunofluorescence, and transmission electron microscopic examination were performed.

RESULTS:

The transmission electron microscopy showed "immunotactoid" extracellular microtubular deposits measuring >30 nm in diameter with a central lucent core.

CONCLUSIONS:

Immunotactoid keratopathy is a distinct type of paraprotein crystalline keratopathy associated with a monocolonal immunoglobulin G kappa light chain (IgGk) protein. Larger case series are needed to determine the clinical significance of this entity.

PMID:
19574898
DOI:
10.1097/ICO.0b013e318191449a
[Indexed for MEDLINE]

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