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J Phys Chem B. 2009 Jul 30;113(30):10196-209. doi: 10.1021/jp902883q.

Aqueous phase behavior of lipids with isoprenoid type hydrophobic chains.

Author information

1
Nanotechnology Research Institute, AIST, Tsukuba Central-5, Higashi 1-1-1, Tsukuba, Ibaraki 305-8565, Japan. hato-m@gsc.riken.jp

Abstract

Aqueous phase behavior of lipids with isoprenoid type hydrophobic chains (hereafter referred to as "isoprenoid-chained lipids") as functions of the chain length and the hydrophilic headgroup type has been examined over a chain length span from 12 to 16 carbon atoms long and a temperature range from -40 to 65 degrees C by using optical microscopy, DSC (differential scanning calorimetry), and SAXS (small-angle X-ray scattering) techniques. Characteristic phase behavior that arises from the unique "isoprenoid-chain" structure was discussed. This work together with previous studies (Prog. Colloid Polym. Sci. 2004, 123, 56-60 and J. Phys. Chem. B 2008, 112, 12286-12296) has clarified the molecular correlation of the aqueous phase behavior of "isoprenoid-chained lipids" over the chain lengths from 12 to 18 carbon atoms and introduced a new lipid library which can form a range of liquid crystals, such as an HII (an inverted hexagonal phase), a QII (an inverted cubic phase), and an Lalpha (a lamellar phase), that are stable over a wide temperature span from 0 degrees C.

PMID:
19572621
DOI:
10.1021/jp902883q

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