Genome-wide significant evidence for association (P < 5 × 10−8, threshold shown by solid red line, SNPs by large red diamonds) was observed at 7 SNPs across 209 kb. P-values are shown for all genotyped and imputed SNPs (25,900,000–27,875,000 bp) for the meta-analysis of European-ancestry MGS, ISC and SGENE samples (8,008 cases, 19,077 controls). Red circles indicate other SNPs with P < 5 × 10−7. Not shown are two SNPs in HLA-DQA1 (6p21.32; lowest P = 6.88 × 10−8, 32,710,247 bp; see ). Locations are shown for RefSeq genes and POM121L2. Pairwise LD relationships are shown for 26 SNPs with P < 10−7 (except that SNPs 5 and 6 are shown, despite slightly larger P-values, to illustrate LD for that segment; and a SNP in strong LD with SNPs 25 and 26 is omitted). LD was computed from MGS European-ancestry genotyped and imputed SNP data. The signal is poorly localized because of strong LD: of the 7 significant SNPs, 7–8 and 9–11 are in nearly perfect LD; they are in or within ~ 30–50 kb of a cluster of 5 histone genes (HIST1H2BJ, HIST1H2AG, HIST1H2BK, HIST1H4I, HIST1H2AH; 27,208,073–27,223,325 bp). These SNPs are in moderately strong LD (r2 = 0.52–0.77) with 2 other significant SNPs 70–140 kb away, upstream of PRSS16 (SNP 13) or between PRSS16 and POM121L2 (SNP18). (See and for additional details.)