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Neonatology. 2010;97(1):10-4. doi: 10.1159/000226602. Epub 2009 Jul 2.

Polymorphisms in the Renin-Angiotensin system and outcome of very-low-birthweight infants.

Author information

1
Department of Pediatrics, University of Lubeck, Lubeck, Germany. spiegler@paedia.ukl.mu-luebeck.de

Abstract

BACKGROUND:

The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity.

OBJECTIVE:

To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants.

METHOD:

Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively.

RESULTS:

There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus.

CONCLUSION:

Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.

PMID:
19571582
DOI:
10.1159/000226602
[Indexed for MEDLINE]

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