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Cell Stem Cell. 2009 Jul 2;5(1):17-26. doi: 10.1016/j.stem.2009.06.016.

Control of stem cell fate by physical interactions with the extracellular matrix.

Author information

1
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA. guilak@duke.edu

Abstract

A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at the nanoscale, ECM mechanical properties, and the transmission of mechanical or other biophysical factors to the cell. Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.

PMID:
19570510
PMCID:
PMC2768283
DOI:
10.1016/j.stem.2009.06.016
[Indexed for MEDLINE]
Free PMC Article

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