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Radiother Oncol. 1991 Oct;22(2):143-4.

Effects of single dose irradiation on pancreatic beta-cell function.

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1
Endocrinology and Diabetes Unit, School of Medicine, Barcelona University, Spain.

Abstract

We have irradiated abdominal cavity of 23 rats with 10 Gy irradiation-induced hypoglycemia on the fourth day after intervention. Islets collected at this time showed an impaired insulin secretion without affecting insulin content. This impairment persisted after one month follow-up with reduced number of beta-cells in morphological examination.

PMID:
1957005
[Indexed for MEDLINE]
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