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Nat Rev Drug Discov. 2009 Jul;8(7):547-66. doi: 10.1038/nrd2907.

Cell cycle kinases as therapeutic targets for cancer.

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1
Oncology Research Centre of Mercogliano, Mercogliano, Avellino, Italy. slapenna@gmail.com

Abstract

Several families of protein kinases orchestrate the complex events that drive the cell cycle, and their activity is frequently deregulated in hyperproliferative cancer cells. Although several molecules that inhibit cell cycle kinases have been developed and clinically screened as potential anticancer agents, none of these has been approved for commercial use and an effective strategy to specifically control malignant cell proliferation has yet to be established. However, recent genetic and biochemical studies have provided information about the requirement for certain cell cycle kinases by specific tumours and specialized tissue types. Here, we discuss the potential and limitations of established cell cycle kinases as targets in anticancer drug discovery as well as novel strategies for the design of new agents.

PMID:
19568282
DOI:
10.1038/nrd2907
[Indexed for MEDLINE]
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