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Radiology. 2009 Sep;252(3):816-24. doi: 10.1148/radiol.2523081584. Epub 2009 Jun 30.

Diffusion-tensor imaging implicates prefrontal axonal injury in executive function impairment following very mild traumatic brain injury.

Author information

  • 1Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA. mlipton@aecom.yu.edu

Abstract

PURPOSE:

To determine whether frontal white matter diffusion abnormalities can help predict acute executive function impairment after mild traumatic brain injury (mTBI).

MATERIALS AND METHODS:

This study had institutional review board approval, included written informed consent, and complied with HIPAA. Diffusion-tensor imaging and standardized neuropsychologic assessments were performed in 20 patients with mTBI within 2 weeks of injury and 20 matched control subjects. Fractional anisotropy (FA) and mean diffusivity (MD) images (imaging parameters: 3.0 T, 25 directions, b = 1000 sec/mm(2)) were compared by using whole-brain voxelwise analysis. Spearman correlation analyses were performed to evaluate associations between diffusion measures and executive function.

RESULTS:

Multiple clusters of lower frontal white matter FA, including the dorsolateral prefrontal cortex (DLPFC), were present in patients (P < .005), with several clusters also demonstrating higher MD (P < .005). Patients performed worse on tests of executive function. Lower DLPFC FA was significantly correlated with worse executive function performance in patients (P < .05).

CONCLUSION:

Impaired executive function following mTBI is associated with axonal injury involving the DLPFC.

PMID:
19567646
DOI:
10.1148/radiol.2523081584
[PubMed - indexed for MEDLINE]
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