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J Rheumatol. 2009 Aug;36(8):1744-8. doi: 10.3899/jrheum.080737. Epub 2009 Jun 30.

Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases.

Author information

1
Medicina Interna, Ospedali Riuniti, Bergamo, Italy. albrucato@ospedaliriuniti.bergamo.it

Abstract

OBJECTIVE:

To study anti-Ro/La-negative congenital heart block (CHB).

METHODS:

Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods.

RESULTS:

There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers.

CONCLUSION:

Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases.

PMID:
19567621
PMCID:
PMC2798588
DOI:
10.3899/jrheum.080737
[Indexed for MEDLINE]
Free PMC Article
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