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Radiat Oncol. 2009 Jun 30;4:19. doi: 10.1186/1748-717X-4-19.

Clinical outcome of breast cancer occurring after treatment for Hodgkin's lymphoma: case-control analysis.

Author information

1
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. almeldin@gmail.com

Abstract

BACKGROUND:

To evaluate diagnosis, management and outcome of breast cancer (BC) occurring after irradiation for Hodgkin's lymphoma (HL).

METHODS:

39 cases of BC in 28 HL survivors were retrospectively reviewed. 21 patients were included in a case-control analysis.

RESULTS:

The median age at diagnosis of HL and BC was 25.3 and 45.3 years, respectively. The median interval to develop BC was 16.1 years. Eleven women (39.2%) had bilateral disease. Mode of detection of the index breast cancers was by mammographic screening in 17 patients (60.7%), palpable lump in 8 patients (28.6%), clinical examination in two patients (7.1%), and unknown in one patient (3.6%). Case-control analysis showed that histological features and prognosis of BC after HL were similar to those of primary BC, however, for BC after HL, mastectomy was the predominant surgery (P = .001) and adjuvant radiotherapy and anthracycline-based chemotherapy were less frequently used as compared to primary BC (P < .001 and .003, respectively).

CONCLUSION:

The previous history of HL does not appear to be a poor prognostic factor for BC occurring thereafter.

PMID:
19566943
PMCID:
PMC2715416
DOI:
10.1186/1748-717X-4-19
[Indexed for MEDLINE]
Free PMC Article

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