Format

Send to

Choose Destination
J Biomed Opt. 2009 May-Jun;14(3):034008. doi: 10.1117/1.3130323.

Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles.

Author information

1
University of California, Irvine, Department of Chemical Engineering, Irvine, California 92697, USA.

Abstract

Contrast in optical coherence tomography (OCT) images can be enhanced by utilizing surface plasmon resonant gold nanoparticles. To improve the poor in vivo transport of gold nanoparticles through biological barriers, an efficient delivery strategy is needed. In this study, the improved penetration and distribution of gold nanoparticles were achieved by microneedle and ultrasound, respectively, and it was demonstrated that this multimodal delivery of antibody-conjugated PEGylated gold nanoparticles enhanced the contrast in in vivo OCT images of oral dysplasia in a hamster model.

PMID:
19566301
PMCID:
PMC2872553
DOI:
10.1117/1.3130323
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Society of Photo-Optical Instrumentation Engineers Icon for PubMed Central
Loading ...
Support Center