Format

Send to

Choose Destination
See comment in PubMed Commons below
Zhong Yao Cai. 2009 Mar;32(3):398-400.

[Protective effect of polysaccharides from sea cucumber on glu-induced neurotoxicity in PC12 cells].

[Article in Chinese]

Author information

1
Weihai International Biotechnology R & D Center of Shandong University, Weihai 264209, China.

Abstract

OBJECTIVE:

To investigate the protective effect of polysaccharides from sea cucumber (HS) on Glu-induced neurotoxicity in PC12 cells.

METHODS:

The toxicity model was established by treating PC12 cells with Glu in vitro. Cell viability was assayed with MTT method. The vitality of antioxidant enzymes (SOD) and the level of malondialdehyde (MDA) and lactic dehydrogenase (LDH) were evaluated by chromatometry.

RESULTS:

The vitality of SOD increased and the levels of MDA and LDH significantly decreased in PC12 cells of HS group compared with the model group. HS in different concentration showed protective effects as it increased the vitality of SOD and decreased the content of MDA and LDH in a dose-dependent manner.

CONCLUSION:

Polysaccharide from sea cucumber can protect PC12 cells from the injury induced by Glu.

PMID:
19565721
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center