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Nat Rev Genet. 2009 Aug;10(8):540-50. doi: 10.1038/nrg2583.

Evolutionary analysis of the dynamics of viral infectious disease.

Author information

1
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. oliver.pybus@zoo.ox.ac.uk

Abstract

Many organisms that cause infectious diseases, particularly RNA viruses, mutate so rapidly that their evolutionary and ecological behaviours are inextricably linked. Consequently, aspects of the transmission and epidemiology of these pathogens are imprinted on the genetic diversity of their genomes. Large-scale empirical analyses of the evolutionary dynamics of important pathogens are now feasible owing to the increasing availability of pathogen sequence data and the development of new computational and statistical methods of analysis. In this Review, we outline the questions that can be answered using viral evolutionary analysis across a wide range of biological scales.

PMID:
19564871
DOI:
10.1038/nrg2583
[Indexed for MEDLINE]

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