Format

Send to

Choose Destination
Cell. 2009 Jun 26;137(7):1181-3. doi: 10.1016/j.cell.2009.06.008.

The juxtamembrane region of EGFR takes center stage.

Author information

1
Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. stevan.hubbard@med.nyu.edu

Abstract

The activation process for the epidermal growth factor receptor (EGFR) involves formation of an asymmetric dimer of the tyrosine kinase domains. Jura et al. (2009) in this issue and Brewer et al. (2009) in Molecular Cell now demonstrate that the juxtamembrane region of EGFR plays a crucial role in stabilizing this dimer.

PMID:
19563749
DOI:
10.1016/j.cell.2009.06.008
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center