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Methods Mol Biol. 2009;521:55-70. doi: 10.1007/978-1-60327-815-7_4.

Checkpoint regulation of DNA replication.

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1
Department of Cell Biology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet Medical Centre, Oslo, Norway.

Abstract

We discuss the mechanisms regulating entry into and progression through S phase in eukaryotic cells. Methods to study the G1/S transition are briefly reviewed and an overview of G1/S-checkpoints is given, with particular emphasis on fission yeast. Thereafter we discuss different aspects of the intra-S checkpoint and introduce the main molecular players and mechanisms.

PMID:
19563101
DOI:
10.1007/978-1-60327-815-7_4
[Indexed for MEDLINE]
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