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J Emerg Trauma Shock. 2008 Jul;1(2):119-22. doi: 10.4103/0974-2700.43198.

Epstein-Barr virus-associated hemophagocytic syndrome mimicking severe sepsis.

Abstract

Severe sepsis is amongst the most common reasons for admission to the intensive care unit (ICU) throughout the world and is a common cause of death. The diagnosis of sepsis is usually straightforward, being based on a constellation of clinical and laboratory features. Noninfectious disorders, including pancreatitis, drug reactions, and autoimmune disorders, may cause a systemic inflammatory response that mimics sepsis. We present the case of a 32-year-old male with Epstein-Barr virus-associated hemophagocytic syndrome who presented to the ICU with features of severe sepsis which progressed to multisystem organ failure and death despite aggressive supportive measures.

KEYWORDS:

Bile ductopenia; Epstein-Barr virus; erythrophagocytic syndrome; hemophagocytic lymphohistiocytosis; hemophagocytic syndrome; multiorgan failure; sarcoid; sepsis; systemic inflammation

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