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Bioorg Med Chem Lett. 2009 Aug 1;19(15):4031-3. doi: 10.1016/j.bmcl.2009.06.026. Epub 2009 Jun 13.

Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors.

Author information

1
Bristol-Myers SquibbPharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA. derek.denhart@bms.com

Abstract

A series of racemic 3-(trans-2-aminomethylcyclopentyl)indoles was synthesized and found to have potent binding to the human serotonin transporter (hSERT). The most active analog was synthesized stereospecifically and the active enantiomer was shown to have high affinity binding to hSERT.

PMID:
19560923
DOI:
10.1016/j.bmcl.2009.06.026
[Indexed for MEDLINE]

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