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J Med Chem. 1991 Nov;34(11):3301-5.

Gossypol and derivatives: a new class of aldose reductase inhibitors.

Author information

1
Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131.

Abstract

Gossypol and 17 derivatives were tested as inhibitors of aldose reductase from human placenta. Gossypol and a number of the derivatives were potent inhibitors. The order of inhibitory activity was interpreted in relation to the Kador-Sharpless pharmacophor model for the aldose reductase inhibitor site. The structural but not the electronic aspects of the model were found to apply to this series of compounds.

PMID:
1956050
DOI:
10.1021/jm00115a021
[Indexed for MEDLINE]

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