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Semin Cell Dev Biol. 2009 Jun;20(4):378-86. doi: 10.1016/j.semcdb.2009.02.005. Epub 2009 Mar 3.

Genes and signaling events that establish regional patterning of the mammalian forebrain.

Author information

1
Department of Psychiatry, University of California, San Francisco, CA 94143-2611, USA. Renee.Hoch@ucsf.edu

Abstract

Embryonic development of the mammalian forebrain is guided by signals from four patterning centers. The concerted actions of these signals transform the anterior neural plate and prosencephalon into discrete forebrain structures including the telencephalon (cerebral cortex and basal ganglia) and hypothalamus. In this review, we describe the signaling, transcriptional, and regulatory events that lead to induction of the prospective telencephalon, and that instruct regional development of distinct telencephalic areas along the rostrocaudal and dorsoventral axes.

PMID:
19560042
DOI:
10.1016/j.semcdb.2009.02.005
[Indexed for MEDLINE]

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