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Clin Perinatol. 2009 Jun;36(2):451-71, xi. doi: 10.1016/j.clp.2009.03.006.

Prenatal stem cell transplantation and gene therapy.

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  • 1Department of Surgery, Children's Center for Fetal Research, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Abramson Research Building, Philadelphia, PA 19104-4318, USA.


At the present time, the most likely and eminent application of stem cell therapy to the fetus is in utero hematopoietic stem cell transplantation (IUHCT), and this stem cell type will be discussed as a paradigm for all prenatal stem cell therapy. The authors feel that the most likely initial application of IUHCT will use adult HSC derived from bone marrow (BM) or peripheral blood (PB), and will focus this article on this specific approach. The article also reviews the experimental data that support the capacity of IUHCT to induce donor-specific tolerance.

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