Format

Send to

Choose Destination
See comment in PubMed Commons below
BMC Evol Biol. 2009 Jun 26;9:142. doi: 10.1186/1471-2148-9-142.

Rodent-specific alternative exons are more frequent in rapidly evolving genes and in paralogs.

Author information

1
Departament of Bioengineering and Bioinformatics, M V Lomonosov Moscow State University, Moscow, Russia. n_ramil@mail.ru

Abstract

BACKGROUND:

Alternative splicing is an important mechanism for generating functional and evolutionary diversity of proteins in eukaryotes. Here, we studied the frequency and functionality of recently gained, rodent-specific alternative exons.

RESULTS:

We projected the data about alternative splicing of mouse genes to the rat, human, and dog genomes, and identified exons conserved in the rat genome, but missing in more distant genomes. We estimated the frequency of rodent-specific exons while controlling for possible residual conservation of spurious exons. The frequency of rodent-specific exons is higher among predominantly skipped exons and exons disrupting the reading frame. Separation of all genes by the rate of sequence evolution and by gene families has demonstrated that rodent-specific cassette exons are more frequent in rapidly evolving genes and in rodent-specific paralogs.

CONCLUSION:

Thus we demonstrated that recently gained exons tend to occur in fast-evolving genes, and their inclusion rate tends to be lower than that of older exons. This agrees with the theory that gain of alternative exons is one of the major mechanisms of gene evolution.

PMID:
19558667
PMCID:
PMC2711938
DOI:
10.1186/1471-2148-9-142
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center