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Sci China C Life Sci. 2009 Jun;52(6):506-14. doi: 10.1007/s11427-009-0082-8. Epub 2009 Jun 26.

Towards transgenic primates: What can we learn from mouse genetics?

Author information

1
Brain and Behavior Discovery Institute, School of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.

Abstract

Considering the great physiological and behavioral similarities with humans, monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human diseases. Various powerful genetic technologies initially developed for making mouse models are being explored for generating transgenic primate models. We review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.

PMID:
19557327
PMCID:
PMC2969839
DOI:
10.1007/s11427-009-0082-8
[Indexed for MEDLINE]
Free PMC Article

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