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Nat Rev Nephrol. 2009 Jul;5(7):367-8. doi: 10.1038/nrneph.2009.77.

Proteinuria: Increased angiotensin-receptor blocking is not the first option.

Abstract

Candesartan doses in excess of the recommended antihypertensive maxima have been reported to lead to greater reductions of proteinuria than the advised doses. High-dose angiotensin-converting-enzyme inhibitors, however, are at least as effective as high-dose angiotensin blockers and less expensive. Angiotensin-converting-enzyme inhibition is thus the first-line strategy to halt kidney disease progression.

PMID:
19556990
DOI:
10.1038/nrneph.2009.77
[Indexed for MEDLINE]

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