Send to

Choose Destination
See comment in PubMed Commons below
Can J Plast Surg. 2007 Fall;15(3):169-72.

Atypical fibroxanthoma in a young woman: An unusual case presentation.

Author information

Department of Surgery, Stony Brook University Medical Center, State University of New York at Stony Brook, Stony Brookt, New York, USA.


Atypical fibroxanthoma (AFX) is an uncommon neoplasm, identified as a spindle cell tumour that is generally found in elderly patients on sun-exposed areas. The majority of cases of AFX are benign, and metastasis is a rare phenomenon. The first case in the literature of AFX is described in a young woman with no previous risk factors who presented with a three-month history of an enlarging nodule of the left nasal alar. Excision showed the lesion to be composed of hyperchromatic, pleomorphic, vacuolated spindle cells and multinucleated giant cells. The tumour cells stained positive for macrophage-histiocyte antigen alpha(1)-antitrypsin, neurokinin-1, CD68 and alpha(1)-antichymotrypsin. The present case report highlights the importance of correct diagnosis for AFX with adequate excision and by considering the histopathology and immunohisto-chemistry of its clinical differential diagnosis.


Atypical fibroxanthoma; Histopathology; Immunohistochemistry; Mohs micrographic surgery

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center