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N Engl J Med. 2009 Jun 25;360(26):2705-18. doi: 10.1056/NEJMoa0808276.

Routine early angioplasty after fibrinolysis for acute myocardial infarction.

Collaborators (196)

Cantor W, Goodman S, Fitchett D, Langer A, Borgundvaag B, Heffernan M, Ducas J, Cohen E, Dzavik V, Mehta S, Lazzam C, Morrison L, Schwartz B, Ohman EM, Berger P, Buller C, Pieper K, Fitchett D, Charron T, Jolly S, Goodman S, Cantor W, Bagnall A, Borgundvaag B, Burstein J, Cantor W, Charron T, Fam N, Fitchett D, Georgescu A, Goldman L, Goodman S, Graham J, Hassan Q, Heffernan M, Kassam S, Kim HH, Prabhakar M, Sheth T, Syed J, Uxa A, Vijayaraghavan R, Wawrzyniak J, Wijeysundera H, Yan A, Tan M, Obispo G, Escobilla G, Francis S, Wawrzyniak J, Georgescu A, Hussan Q, Camara D, Singh P, Gebru A, Oh M, Minott D, Spindler C, Datoo M, Kornilova O, Dinulos M, Goodman S, Cantor W, Zile B, Wawrzyniak J, Fry A, Lazzam C, Carter A, Cohen E, Balleza L, Hsu E, Ducas J, Aceves SL, Muno A, Dzavik V, Patel A, Atchison D, Miner S, Robbins K, Kassam SA, Hart B, Bozek B, Kim HH, Janzen I, Mehta SR, Brons S, Sridhar K, Oke T, Schampaert E, Mercure C, Pageau P, Maingi M, Durdos R, Choi R, Duic M, Vardy C, Wilkinson D, Buss A, Lubelsky BJ, Sommer L, Coldwell J, Burstein J, Dhingra S, Hancock D, Harrison C, Eyman T, Cherry JM, Vertes G, Pape G, Ross B, Tam M, Burke B, Snow S, Kong WH, Butchey J, Hutton D, Lee A, Borts D, Coons M, Bhargava R, Vandersluis R, Novak T, Easton J, Bouwmeister J, Lafrance L, Lee A, Borts D, Kajil M, Heffernan M, Martin L, Franks R, Kassam SA, Moss F, Hart B, Bozak B, Pallie S, Sharma A, Krekorian S, Lefkowitz C, Tyberg J, Klakowitz E, Walters N, Thornley M, Ducas J, Munoz A, Aceves SL, Ali N, Robichaud L, Palatnick W, Munoz A, Aceves SL, de Faria R, Munoz A, Aceves SL, Ducas J, Munoz A, Aceves SL, Krishnan N, McBride C, Kennedy D, Robinson M, Mensour M, Tumber S, Borgundvaag B, Barolet A, Loftus M, Mann M, Balmain Y, Gardiner J, Greene NK, Turney N, Chiu S, Marshall KJ, Kumar G, Peart M, Hirst J, Johnston L, Ducas J, Manca G, Munoz A, Aceves SL, Torossi G, Munoz A, Aceves SL, Fowlis R, Janzen I, Shearing A, Lorbetsky D, Gangbar E, Ahluwalia N, Zimakas G, Zaniol D, McKinnon J, Miller L, Belley E, Vincent J.

Author information

Southlake Regional Health Centre, Newmarket, ON, Canada.



Patients with a myocardial infarction with ST-segment elevation who present to hospitals that do not have the capability of performing percutaneous coronary intervention (PCI) often cannot undergo timely primary PCI and therefore receive fibrinolysis. The role and optimal timing of routine PCI after fibrinolysis have not been established.


We randomly assigned 1059 high-risk patients who had a myocardial infarction with ST-segment elevation and who were receiving fibrinolytic therapy at centers that did not have the capability of performing PCI to either standard treatment (including rescue PCI, if required, or delayed angiography) or a strategy of immediate transfer to another hospital and PCI within 6 hours after fibrinolysis. All patients received aspirin, tenecteplase, and heparin or enoxaparin; concomitant clopidogrel was recommended. The primary end point was the composite of death, reinfarction, recurrent ischemia, new or worsening congestive heart failure, or cardiogenic shock within 30 days.


Cardiac catheterization was performed in 88.7% of the patients assigned to standard treatment a median of 32.5 hours after randomization and in 98.5% of the patients assigned to routine early PCI a median of 2.8 hours after randomization. At 30 days, the primary end point occurred in 11.0% of the patients who were assigned to routine early PCI and in 17.2% of the patients assigned to standard treatment (relative risk with early PCI, 0.64; 95% confidence interval, 0.47 to 0.87; P=0.004). There were no significant differences between the groups in the incidence of major bleeding.


Among high-risk patients who had a myocardial infarction with ST-segment elevation and who were treated with fibrinolysis, transfer for PCI within 6 hours after fibrinolysis was associated with significantly fewer ischemic complications than was standard treatment. ( number, NCT00164190.)

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