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Bioorg Med Chem Lett. 2009 Aug 1;19(15):4059-63. doi: 10.1016/j.bmcl.2009.06.021. Epub 2009 Jun 13.

Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3).

Author information

1
Department of Medicinal Chemistry, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA. scott_d_kuduk@merck.com

Abstract

A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.

PMID:
19553111
DOI:
10.1016/j.bmcl.2009.06.021
[Indexed for MEDLINE]

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