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J Eur Acad Dermatol Venereol. 2010 Jan;24(1):32-7. doi: 10.1111/j.1468-3083.2009.03347.x. Epub 2009 Jun 22.

Expression of human neutrophil proteins in acne vulgaris.

Author information

1
Gazi University, Department of Dermatology, Ankara, Turkey. eozsoy@gazi.edu.tr

Abstract

BACKGROUND:

In acne vulgaris patients, the presence of a dysregulation of the production of innate and specific antimicrobial peptides has been postulated.

OBJECTIVE:

This study aims to determine whether human neutrophil proteins (HNP) 1-3 are expressed in acne patients.

MATERIALS AND METHODS:

HNP 1-3 expression was investigated in 35 acne patients treated with isotretinoin and in 25 healthy subjects. At the beginning of the study, two skin biopsies were taken from acne patients; one biopsy was taken from an established pustule and one from uninvolved skin, and the biopsies were repeated after treatment. Only one biopsy was obtained from controls.

RESULTS:

The statistical analysis showed that pustular lesions of acne patients had significantly higher levels of perivascular and interstitial HNP 1-3 expression when compared with the biopsy of uninvolved skin of these patients (P = 0.003, P = 0.001, respectively) and with that of healthy controls (P = 0.007, P = 0.014, respectively). Isotretinoin treatment achieved a decrease in the perivascular and interstitial HNP 1-3 expression of pustular lesions (P = 0.01, P = 0.001, respectively).

CONCLUSION:

Our current study demonstrates the novel observation that a recently identified antimicrobial peptide, HNP 1-3, is expressed in neutrophils of acne inflammation but not in uninvolved skin of these patients. These results suggest that HNP 1-3 may contribute to the development of inflammatory lesions of acne.

[Indexed for MEDLINE]

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