Format

Send to

Choose Destination
See comment in PubMed Commons below
Wei Sheng Yan Jiu. 2009 May;38(3):265-9.

[Study of serotonin transporter gene polymorphisms in disease of patients with abnormal black Savda].

[Article in Chinese]

Author information

1
College of Life Science and Technology, Xinjiang University, Urumqi 830046, China. daiwencheng007@yahoo.com.cn

Abstract

OBJECTIVE:

To explore the association between patients with abnormal black Savda according to Uighur medicine theory and the serotonin transporter (5-HTT) gene polymorphisms in the promoter (5-HTTLPR) and the variable number tandem repeats (VNTRs) in intron 2 (5-HTTVNTR).

METHODS:

Divided the patients into four body fluids according to Uighur medicine theory, PCR was used to detect genotype and allele frequencies of 5-HTILPR and 5-HTTVNTR polymorphisms in 66 patients with abnormal black Savda (including 35 cases of hypertension, 19 cases of diabetes, 12 cases of cancer diagnosis) and 45 control subjects.

RESULTS:

No significant differences for the genotype frequency or the allele frequency of 5-HTTLPR and 5-HTTVNTR were revealed between patients with abnormal black Savda and control subjects. More control subjects tended to be of L/L genotype (15.56%) than hypertension with abnormal black Savda (5.72%). On the contrary, more cancer diagnosis with abnormal black Savda tended to be of L/L genotype (25.00%) and L (54.17%) allele than control subjects L/L genotype (15.56%) and L allele (37.78%). On the other hand, fewer control subjects tended to be of 10/10 genotype (4.45%) than diabetes with abnormal black Savda (10.53%) and cancer diagnosis with abnormal black Savda (8.34%).

CONCLUSION:

5-HTTLPR L/L genotype may be a protective factor for hypertension with abnormal black Savda, 5-HTTLPR L/L genotype and L allele may be risk factors for cancer diagnosis with abnormal black Savda, 5-HTTVNTR 10/10 genotype may be risk factors for cancer diagnosis with abnormal black Savda and diabetes with abnormal black Savda.

PMID:
19548561
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center