E3 ligases involved in Mdm2-independent p53 ubiquitination. Domains, ubiquitination type, and function of E3 ligases that regulate Mdm2-independent p53 ubiquitination. CHY, cysteine/histidine zinc finger; RING, RING finger domain; R-rich, arginine-rich domain; K-rich, lysine-rich domain; ARDL, Armadillo-like domain; UIM, ubiquitin-interacting motif; WWE, conserved sequence of two tryptophan residues followed by a glutamine residue; N-rich, asparagine-rich; T-rich, threonine-rich; HECT, HECT domain; TPR, tetratricopeptide repeat domain; Helical, helical region; Ub activity, required for ubiquitin ligase activity; C2H2, cysteine2/histidine2 zinc finger; FYVE, FYVE ring finger domain; C2, protein kinase C conserved region 2; WW, two conserved tryptophans domain; Ub, ubiquitination