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Clin Immunol. 2009 Oct;133(1):78-85. doi: 10.1016/j.clim.2009.05.014. Epub 2009 Jun 21.

Selective IgA deficiency in early life: association to infections and allergic diseases during childhood.

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Division of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-14186 Stockholm, Sweden.


Selective IgA deficiency in early life is quite common in Caucasian populations, but it is unclear whether it increases the risk of infections and allergic diseases during childhood. Serum IgA levels were measured in 2423 children at 4 years of age in a Swedish population based birth cohort (BAMSE). Parental questionnaires were repeatedly sent out during the child's first 8 years of life, collecting information about infections and allergic diseases. 14 children (1:173) were found to be IgA deficient at 4 years of age. These children had an increased risk of pseudocroup at year 1 (p<0.01) and food hypersensitivity at year 4 (p<0.05) as compared to IgA sufficient children. No increased risk was observed in the partial IgA deficiency group. The findings suggest that selective IgA deficiency may increase the risk of parentally reported pseudocroup and food hypersensitivity during early childhood.

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