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J Control Release. 2009 Oct 15;139(2):160-6. doi: 10.1016/j.jconrel.2009.06.010. Epub 2009 Jun 21.

Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug.

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Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Bei Yi Jie No.2, 100190 Beijing, China.


Heat treatment is introduced as a simple method for the encapsulation of low molecular weight water-soluble drugs within layer-by-layer assembled microcapsules. A water-soluble drug, procainamide hydrochloride, could thus be encapsulated in large amount and enriched by more than 2 orders of magnitude in the assembled PDADMAC/PSS capsules. The shrunk capsules could control the unloading rate of drugs, and the drugs could be easily unloaded using ultrasonic treatment. The encapsulated amount could be quantitatively controlled via the drug concentration in the bulk. We also found that smaller capsules possess higher encapsulation capability.

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