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Biochim Biophys Acta. 2009 Sep;1791(9):845-9. doi: 10.1016/j.bbalip.2009.05.011. Epub 2009 Jun 18.

Phospholipase D in endocytosis and endosomal recycling pathways.

Author information

1
Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 2503, Bethesda, MD 20892, USA. jdonalds@helix.nih.gov

Abstract

The discovery that Arf GTPases, mediators of membrane traffic, activate phospholipase D (PLD) raised the possibility that Arfs could facilitate membrane traffic by altering membrane lipid composition. PLD hydrolyzes phosphatidylcholine to generate phosphatidic acid (PA), a lipid that favors membranes with negative curvature and thus can facilitate both membrane fission and fusion. This review examines studies that have reported a role for PLD in endocytosis and membrane recycling from endocytic pathways.

PMID:
19540357
PMCID:
PMC2731818
DOI:
10.1016/j.bbalip.2009.05.011
[Indexed for MEDLINE]
Free PMC Article

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