Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem Pharmacol. 2009 Oct 1;78(7):756-65. doi: 10.1016/j.bcp.2009.06.011. Epub 2009 Jun 18.

Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction.

Author information

1
Department of Neurobiology, University of Chicago, Abbot Hall 402-MC0926, Chicago, IL 60637, USA. apgovind@uchicago.edu

Abstract

A major hurdle in defining the molecular biology of nicotine addiction has been characterizing the different nicotinic acetylcholine receptor (nAChR) subtypes in the brain and how nicotine alters their function. Mounting evidence suggests that the addictive effects of nicotine, like other drugs of abuse, occur through interactions with its receptors in the mesolimbic dopamine system, particularly ventral tegmental area (VTA) neurons, where nicotinic receptors act to modulate the release of dopamine. The molecular identity of the nicotinic receptors responsible for drug seeking behavior, their cellular and subcellular location and the mechanisms by which these receptors initiate and maintain addiction are poorly defined. In this commentary, we review how nicotinic acetylcholine receptors (nAChRs) are upregulated by nicotine exposure, the potential posttranslational events that appear to cause it and how upregulation is linked to nicotine addiction.

PMID:
19540212
PMCID:
PMC2728164
DOI:
10.1016/j.bcp.2009.06.011
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center