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Semin Immunol. 2009 Aug;21(4):215-22. doi: 10.1016/j.smim.2009.05.001. Epub 2009 Jun 17.

RIG-I-like receptors: sensing and responding to RNA virus infection.

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The Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Quebec, Canada.


Viral and microbial pathogens contain specific motifs or pathogen-associated molecular patterns (PAMPs) that are recognized by cell surface- and endosome-associated Toll-like receptors (TLRs). RNA virus infection is also detected through TLR-independent mechanisms. Early viral replicative intermediates are detected by two recently characterized cystolic viral RNA receptors-RIG-I and MDA-5. Both are DExDH/box RNA helicases, and RIG-I specifically recognizes 5'-triphosphate containing viral RNA and transmits signals that induce type I interferon-mediated host immunity against virus infection. In this review, we will focus on RIG-I-like receptor (RLR) signal transduction and the regulatory mechanisms - ubiquitination, deubiquitination, ISGylation - underlying this important host response.

[Indexed for MEDLINE]

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