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Ann N Y Acad Sci. 2009 May;1165:190-4. doi: 10.1111/j.1749-6632.2009.04029.x.

Probiotic therapy in radiation-induced intestinal injury and repair.

Author information

1
Division of Gastroenterology, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63110, USA. mciorba@im.wustl.edu

Abstract

Intestinal injury from ionizing radiation is a clinically important entity, as enteritis symptoms occur commonly after radiotherapy for pelvic malignancies. Preventative or therapeutic options for radiation enteritis are mostly unsatisfactory; however, available data suggests that probiotic bacteria--those which confer health benefit--may have therapeutic value. Previous reports from both human trials and animal models have evaluated various end points for probiotic usage in limiting radiation-associated intestinal damage. Newer data suggests that particular probiotics and/or their secreted or derived bacterial products may have unique radioprotective properties. We will review the area with a focus on new developments surrounding probiotic therapy in radiation-induced intestinal injury and repair.

PMID:
19538306
PMCID:
PMC4063203
DOI:
10.1111/j.1749-6632.2009.04029.x
[Indexed for MEDLINE]
Free PMC Article

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