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Diabet Med. 2009 Jun;26(6):617-21. doi: 10.1111/j.1464-5491.2009.02731.x.

Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials.

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Department of Endocrinology, Centre Hospitalier Universitaire de Grenoble, Pôle Digidune, Clinique d'Endocrinologie, BP 217X, Grenoble 38043, France.



Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation.


The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10).


The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients.


HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.

[Indexed for MEDLINE]

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