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Expert Opin Pharmacother. 2009 Aug;10(11):1793-804. doi: 10.1517/14656560903018911.

The treatment and prevention of knee osteoarthritis: a tool for clinical decision-making.

Author information

1
Frederiksberg Hospital, The Parker Institute, DK-2000 Copenhagen F, Denmark. hb@frh.regionh.dk

Abstract

BACKGROUND:

Osteoarthritis (OA) is a major cause of disability, which will increase further with longer lifetime and higher average weight of the population.

OBJECTIVE:

To review a hierarchy of interventions for OA in clinical practice, and compare it with the Strength of Recommendation (SOR) proposed by the Osteoarthritis Research Society International (OARSI).

METHODS:

Search for relevant randomized controlled trials in databases, as well as published systematic reviews and meta-analyses.

RESULTS/CONCLUSIONS:

Preventive measures are few and uncertain; however, basic therapy includes reduction in weight in the obese and exercises to keep in shape; this is in accordance with the OARSI guidelines (OARSI, 100% consensus) emphasizing the need for obese individuals with knee OA to lose weight (OARSI, SOR = 96%). There are indications of an effect of some nutraceuticals, though further studies are needed for validation (OARSI, SOR = 63%). Pharmacological treatment has paracetamol as primary prescription, which is a safe, albeit weak analgesic. Supplementary medications are prescribed according to level of pain and possible inflammation.

PMID:
19537998
DOI:
10.1517/14656560903018911
[Indexed for MEDLINE]
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